Which prostaglandin (PG) is involved in initiating inflammation in the body?

PGE2 is the prostaglandin that plays a significant role in initiating and promoting inflammation in the body. This molecule is produced at the site of tissue injury or infection and contributes to the inflammatory response by enhancing blood flow, increasing vascular permeability, and promoting the delivery of immune cells to the affected area. PGE2 works by binding to its specific receptors on various cells, leading to the activation of cellular signaling pathways that facilitate the inflammatory process. This makes it a critical mediator in the body's defense mechanism against injury and infection, as well as in processes such as fever and pain perception.

While other prostaglandins also have roles in inflammation, PGE2 is particularly noted for its strong association with the onset and amplification of the inflammatory response, distinguishing it as a key player in this physiological process.